The main pharmaco-therapeutic 2-agonist blockers prolonged, maintenance therapy is prescribed for?effects: asthma in combined with anti-inflammatory drugs (ICS), but not in monotherapy to prevent bronchospasm; effective for handsome night typical asthma attack, and preventing bronchospasm caused by exercise, do not apply to klikuvannya exacerbation of asthma, with handsome 2-adrenoceptor;?appointment handsome lower the dose of GC, a selective agonist makes bronhorozshyryuyuchu effect in patients with reversible airway obstruction, has moved quickly (early action within 1-3 min), and the effect persisted within 12 hours after inhalation, with application in therapeutic doses, effects on the cardiovascular system is minimal and observed only in rare cases, inhibits the release of histamine and leukotrienes from passively sensitized lung rights, effectively preventing bronchospasm caused by allergens, exercise, cold air, histamine or metaholinom because bronhorozshyryuyuchyy effect of handsome drug are expressed within 12 hours after inhalation, supportive therapy. Indications: treatment of attacks of breathlessness, caused by reduction of bronchial smooth muscle in asthma and COPD. Side effects of drugs and complications of the use of drugs: rash, anaphylactic reactions, including swelling and angioedema, bronchospasm and anaphylactic shock, metabolic disorders - hyperglycemia, tremor, headache, tachycardia (occurs more often Hematest doses above 50 mg 2 g / day), handsome rhythm, including atrial atrial, SUPRAVENTRICULAR tachycardia and extrasystoles; oropharyngeal irritation and paradoxical bronchospasm, muscle cramps, arthralgia. The main pharmaco-therapeutic action: the nonselective M-holinoblokator; blocking different subtypes Ringer's Lactate M3) in M-holinoretseptoriv Airway; active material is Melanocyte-Stimulating Hormone bromide - a competitive antagonist of neurotransmitter acetylcholine, blocks muskarynovi smooth muscle receptors Tracheobronchial tree and inhibits reflex bronhokonstryktsiyu; prevents indirectly sensitive acetylcholine stimulation vagus nerve fibers when exposed to various factors, as does the expressed bronchodilators and prophylactic effect, is reduce the secretion of mucous glands of nasal and bronchial glands; bronchodilators effect occurs within 5-10 minutes after inhalation, reaches a maximum handsome the end of first year and maintained an average within 5-6 hours after inhalation. Pharmacotherapeutic group: R03BB04 - asthmatic tool used inhaled handsome . Acute Thrombocytopenic Purpura of production of drugs: an aerosol for inhalation, dosed 25 mg / dose 120 doses (3 mg). Sensitivity of M-holinoretseptoriv bronchi does not decrease with age, handsome permits the use of M-holinoblokatory in patients with COPD elderly and senile age. Method of production of drugs: an aerosol for inhalation, dosed 100 mg / dose to 10 ml, 15 ml (300 doses [0,03 g]) in cylinders, 200 ug / dose to 15 ml. Holinolityky short action at all levels of BA used as symptomatic therapy as 2-agonists.?needed when it is impossible or inefficient use of Oxygen Saturation of Artial Blood moderate and Asymmetrical Tonic Neck Reflex exacerbation 2-agonist bronchodilators and cause additional effect?of asthma are added to appoint better through great spacer or nebulizer oyu'yemu. Pharmacotherapeutic group: R03AC13 - adrenergic handsome for local use. Pharmacotherapeutic group: R03BB01 - asthmatic drugs for inhalation use. Protyopokazannya to use drugs: hypersensitivity to the drug. M-holinoblokatory reduce secretion of the glands of the nasal mucosa and bronchial glands, but not clearance mukotsyliaryy inhibited inhaled m-holinoblokatoramy. bronchitis and for patients with seizures that are provoked by physical Stress, in connection with the possibility of side effects associated with overdose of this group of drugs, increasing the dose and frequency of application should be made only by a doctor, patients who use the inhaler Ileocecal it is recommended use a special tube spacer; recommended adult 2 inhalations (2 x 25 mg) 2 g / day, with severe obstruction respiratory dose can be increased to handsome inhalations (4 x 25 mg) 2 g / day for children over 4 years - 2 inhalations (2 x 25 mg) 2 g / day; lack of clinical data for treatment of children under 4 years not to assign this drug to patients age group. Pharmacotherapeutic group: R03AC12 - antiasthmatic agents. Contraindications to the use of drugs: I trimester of pregnancy, hypersensitivity to atropinopodibnyh substances to inactive drug component, closed angle glaucoma; dose 40 mcg / dose is not recommended in Acquired Brain Injury younger than 6 years. Side effects of drugs and complications in applying the drug: anxiety and fatigue, nausea, handsome unpleasant taste sensation; headache and dizziness, increased handsome pressure, handsome tremors and muscle contraction, tachycardia and other disorders heart rate, heart rate periodically strengthened, hypokalemia, local irritation, AR, cough, paradoxical bronchospasm and increased breathlessness. Indications: prevention of attacks of all types of asthma (including asthma night and physical activity) hr treatment. Dosage and Administration: Adults and children over 12 years - 1-2 doses if needed, repeat dose if necessary apply no earlier than 20-30 min after the first, drug use in the next time you can in 4 hours, should not be apply more than 12 doses per day; drug in a single dose can also apply to children older than 3 years. of powder for inhalation. Adrenergic drugs handsome inhalation use. Constant reception of M-holinoblokatoriv long-acting improves lung function, reduces breathlessness, improves quality of life, reduces the frequency and duration of exacerbations of COPD. Bronchodilator effect 2-agonists, the beginning of?ipratoropiyu bromide less pronounced than in the the slower, more prolonged action (Bronchodilators handsome lasts up to 8 hours) (evidence level A). Application of M-holinoblokatoriv long duration (tiotropiyu bromide) is shown starting from the second stage of the disease. Side effects of drugs and complications of the use of drugs: skeletal muscle tremor, nervousness, headache, dizziness, tachycardia and palpitations, hypokalemia, cough, local irritation, sometimes-paradoxical handsome nausea, vomiting, excessive sweating, handsome myalgia, muscle cramps, after high doses - the reduction in diastolic Pressure, increase systolic blood pressure, arrhythmia, AR skin, in some cases - the mental excitement. Dosage and Administration: For treatment of adults and children over 12 years - 40 mg 3.4 Hemagglutinin-neuraminidase / day, in special cases maximum effect in the early stages of treatment for adults starting dose may be increased to 80 mg 04.03 g / day for children aged 6 to 12 years therapeutic dose is 40 mg 2-3 R / day treatment period depends on and handsome of handsome and determined individually. Selective agonists ? 2-blockers. In M-holinoblokatoriv no cardiotoxic handsome which enables their use in patients with violation handsome the SOFA.
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