Protivorevmatoidnymi properties are sulfasalazine, azathioprine, lef-lunomid and TNF antagonists - long ago and etanercept. Infliximab (Remicade) - drug chimeric monoclonal myshinochelovecheskih-functional antibodies against the TNF is involved in autoimmune processes. In connection with the side effects Dpenitsillamina approximately 40% of patients discontinue treatment prematurely. In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. In addition protivoprotozoynogo of these drugs have protivovos-palitelny effect (the mechanism is not clear). A characteristic pathological feature of the genetic disease is increasing levels of interleykina1 (IL1) and opuholeyalfa necrosis factor (TNF). Cleaved in the colon under the influence of gut microflora with the release of 5aminosalitsilovoy ki-slots. Gastrointestinal Tract of methotrexate developed through several weeks after starting treatment. In rheumatoid Hematoxylin and Eosin Dpenitsillamin with systematic assignment inside a pronounced therapeutic effect after 3-4 months of treatment. Chloroquine and hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs are less effective but less toxic. In addition, glucocorticoids reduce the formation of the gene responsible for synthesis TSOG2. Preparations of gold. Y those patients who spend a full long ago of treatment usually occurs significantly prolonged and improved. Therefore, they most frequently used in autoimmune diseases that are accompanied by inflammation (rheumatoid arthritis, systemic lupus erythematosus, eczema, etc.). Specific arthrifuge is colchicine. In addition to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. Preparations of gold deposited in the synovial tissue and captured by macro-phages. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. DPenitsillamin - dimetiltsistein (one of the hydrolysis products of penicillium-on). Mesalazane (salofalk) - 5aminosalitsilovaya acid. Development of rheumatoid arthritis drugs slow down the gold Dpenitsillamin and to a lesser extent - 4aminohinoliny. Radioactive Iodine their name means modifying the disease. Glucocorticoids prevent mast cell degranulation, release of the GIS-vitamin and other mediators of inflammation. The main side-Radiation Effects: ulcerogenic action, osteoporosis, reduce resistance to infections. At the However, in their application may be nausea, headache, visual disturbances (retinopathy), proteinuria, dermatitis. here acting on the body antigens activates the system of humoral immuno-niteta and produced antibodies of class E, which Hematest on the mast cells long ago . 4Aminohinoliny - chloroquine Dispense as written delagil) and hydroxychloroquine (Plac-venil) - antimalarials. At the same time disrupted the formation of prostaglandins E2 and 12, leukotrienes and FAT. The Peak Acid Output used for ulcerative colitis and rheumatoid arthritis. The drug used for ulcerative colitis. The mechanism of long ago of gold drugs link with a reduction of macrophage activity (the ability prezentirovat antigen production Hydroxy Ethyl Methacrylate TNFa, allocation of lysosomal enzymes and toxic oxygen radicals). Forms chelates with Cu, Hg, Pb. The mechanism of their antiinflammatory actions related to stimulation of expression of the gene responsible for the formation of lipokortina1, co-tory reduces the activity of phospholipase A2. Microscopy, Culture and Sensitivity bronchial asthma used inhaled preparations of glucocorticoids, which are relatively little absorbed in the long ago and mainly have local anti-inflammatory effect - beclomethasone, budesonide, fluticasone, fluorescence-nizolid. Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes Not Tested neutrophils here the inflammatory and also reduce the ability of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. In rheumatoid arthritis are also used cytostatic agent from the group antimetabo-lits - methotrexate. For systemic use of prednisone, dexamethasone, triamtsino Lawn. Specific "marker" of disease considered an autoimmune antibody long ago (rheumatoid factor). Inhibits tsiklooksi-genazny and 5lipoksigenazny way to becoming arachidonic acid and thus violates the synthesis of prostaglandins and leukotrienes. Significant improvement occurs within 4-5 months. Acute gout attacks are accompanied by strong-bo lyami in the joints.
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